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Beta-Alanine Stark Pharm - Beta-Alanine (200 grams)
Beta-Alanine by Stark Pharm is recommended for use to increase the intensity of exercise.
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Data sheet
This product has following properties
| Country | Ukraine |
| Weight | 200 g |
| Type of packaging | jar |
| Number of servings | 66 |
| Release form | powder |
| Taste | without flavor additives |
Description
Beta-Alanine by Stark Pharm is a muscle tissue protector and a powerful buffer that enhances muscle endurance - beta-alanine. The supplement is used by both athletes and people who maintain a healthy lifestyle. Regular intake of beta-alanine allows you to increase the number of repetitions with your working weight in sets with medium intensity - a weight that you can do 8-12 times with. Also, the recovery time after the approach is reduced, which makes it possible to do a few more sets. As a result, during recovery with proper nutrition, muscle volume increases. Of course, this is also reflected in the power characteristics, which are increased.
Beta-Alanine has a positive effect on the central nervous system, as well as immunity. Portions of 500-1000 mg per day already noticeably improve well-being and overall productivity. Sports portions - 3000 mg - directly affect the growth of strength and speed-strength characteristics. Beta-Alanine has found wide popularity among weightlifters and in crossfit, where explosive power and strength are needed. MMA and martial arts fighters in most cases respond positively to this drug, especially after OFP training. Sports nutritionists recommend taking Beta-Alanine in courses of 3-5 weeks, after taking a short break.
The effect of taking Beta-Alanine Stark Pharm
- Increases overall and strength endurance
- Increases efficiency and productivity
- Reduces recovery time between sets
- Accelerates recovery processes after any heavy physical exertion
- Slows down the process of protein breakdown
- Maintains a positive nitrogen balance
- Has anti-catabolic properties
Additional Information:
There is a direct correlation between the age-related decline in beta-alanine and testosterone. Carnosine, like beta-alanine, performs many functions: reduction of lipid and protein oxidation; increased ATPase activity; regulation of macrophage function; protection of cell membranes; the formation of chelates of divalent cations, etc., including those associated with the aging process. An important aspect is participation in neurogenic regulation, especially in memory processes.
Scientific review of the available literature from June 2018
Beta-Alanine: A Small Key to Big Success!
Made by order of Stark Pharm
In the process of training and preparing for competitions, the athlete is faced with the problem of muscle fatigue and reduced performance. It is in such a situation that competent pharmaceutical support is needed, which will help to overcome a number of physiological limitations and reach a new level. One of the most effective and at the same time completely natural and safe supplements is beta-alanine.
Beta-alanine is a non-canonical amino acid that is part of carnosine, a fundamentally important molecule in muscle tissue.
In modern English-language professional scientific journals, the following key facts about beta-alanine and carnosine have been highlighted:
- maintains acid-base balance in the muscles;
- reduces fatigue;
- improves performance in various activities;
- increases the efficiency of the athlete;
- complex action antioxidant;
- binds heavy metals;
- stimulates cell cleansing from abnormal proteins [1, 2].
The origin of beta-alanine and application features
Beta-alanine is a completely natural substance found in small amounts in animal products (mainly meat) and vegetable origin [3]. In addition, this amino acid is synthesized in the human liver [1]. Thus, the intake of beta-alanine does not bring anything foreign into the body.
A large part of the successful human studies have used beta-alanine dosages of 2-6.4 g per day, divided into 2-4 equal portions per day, for a course of 4-8 weeks; examples of individual works are [4, 5, 6].
Attention! In pharmacology, it is customary to calculate the dosage for a certain "standard" adult weighing 70 kg. If your weight is greater, the dose of beta-alanine must be increased. Failure to comply with this principle may lead to the absence of the effect of the supplement.
Mechanism of action of beta-alanine
The effect of beta-alanine is realized through carnosine. Carnosine is a dipeptide and is a compound of 2 amino acids - beta-alanine itself and L-histidine. Synthesis of carnosine occurs with the help of the enzyme carnosine synthetase. It is shown that it is the amount of beta-alanine that is the factor that limits the formation of carnosine. Therefore, it is possible to increase the level of carnosine by additional intake of beta-alanine [7]. Histidine is one of the main proteinogenic amino acids and is supplied in sufficient quantities with food. In the body, carnosine is found predominantly in skeletal muscles and the central nervous system.
The breakdown of carnosine is due to the action of another enzyme, carnosinase, which is found in blood serum, liver, and kidneys [8]. There is no benefit to supplementing with "ready-made" carnosine, as the carnosine will be broken down by carnosinase before reaching the muscles and eventually the body will get 2 separate amino acids.
For an athlete, including a bodybuilder, the ability of carnosine to maintain acid-base balance in muscle tissue is most important [9]. In the process of performing various exercises in the muscles, aerobic and anaerobic breakdown of glucose occurs. As part of anaerobic processes, lactate and hydrogen ions H + are formed from pyruvic acid, they are also protons. An increase in the concentration of hydrogen ions means acidification of the medium [10]. As a result, there are unpleasant sensations in the muscles, fatigue, weakness, and a drop in performance.
The carnosine molecule binds protons and in this way weakens the resulting increased acidity and the negative effects associated with it, acting as a so-called buffer system. Ultimately, the athlete works more efficiently and gets less tired, which means he achieves better results and increases his chances of winning.
The physiological functions of carnosine are very diverse and also include the binding of heavy metal ions, complex antioxidant activity, stimulation of the degradation of abnormal proteins in the cell, participation in the regulation of the release of nitric oxide, and hence in the regulation of vascular tone. [eleven].
Security
When using beta-alanine, a slight tingling sensation on the skin, the so-called paresthesia, may occur. Most often, this phenomenon is observed in the face, neck, back of the hands. Typically, the tingling disappears 60-90 minutes after taking the supplement [12]. This effect is widely reported in the literature, no evidence of harm has been described.
The study [13] showed that beta-alanine interacts with specific TGR7 receptors, which are located on the membranes of certain neurons of the dorsal (sensitive) roots of the spinal cord. The endings of these neurons are located in the skin. Activation of TGR7 receptors has been suggested to play an important role in causing paresthesia when taking beta-alanine.
Canadian scientists have demonstrated significant variability in individual tingling sensations in humans when consuming beta-alanine [14]. Thus, the absence or presence of tingling is not an indicator of the quality and effectiveness of the additive.
The international sports nutrition community has recognized beta-alanine supplementation as safe when recommended dosages are followed [1].
Beta-alanine and sports
The use of beta-alanine is most useful in short-term activities (up to 4 minutes), where acidification of the environment in muscle tissue is the limiting factor [2].
So, Belgian scientists modulated the conditions of the final sprint for cyclists, when it is important to make a strong jerk before the finish line. Subjects took 2 g per day at the start of the study and 4 g per day at the end of the 8-week course. As a result, there was an increase in peak (by 11.4%) and average (by 5%) power in exercise on a bicycle ergometer [4]. Successful results were also obtained in rowers, swimmers, and runners [1].
The study [5] recorded an increase in the results in the test for isometric endurance of the knee extensor muscles, namely the 4-headed thigh muscle. People took 8 servings of beta-alanine per day, for a total of 6.4 g.
One of the most important limiters of athletic performance is athlete fatigue. The onset of fatigue is influenced by various central and peripheral factors. Fatigue can be objectively assessed using the so-called physical performance test at threshold values for the frequency of cardiovascular contractions, the test is performed on a bicycle ergometer. In the work of American scientists [15], a group of people took beta-alanine for 28 days and showed a significant improvement in the performance of this test compared to the group taking placebo. The dosage was 1.6 g of beta-alanine per dose, on day 4 of the dose, for a total dosage of 6.4 g per day.
Another study showed the ability of beta-alanine supplementation to improve the performance of a similar test on a bicycle ergometer and a test of getting up from a chair, even in older people, when muscle tissue weakens with age [16]. The subjects took 2.4 g of beta-alanine per day, the portion was divided into 2 equal parts. These results are quite consistent with the ideas about the mechanisms of action of beta-alanine and carnosine.
Given the extensive literature on the effects of beta-alanine, the supplement has been studied in terms of military use. The soldiers took 6 g of beta-alanine per day for 28 days. At the end of the course, the military showed an increase in the performance of the army tests for jumping and shooting compared to the control group [6].
Thus, beta-alanine gives a significant gain in results in various types of short-term activity.
Beta-Alanine and Longevity
Reactive oxygen species are recognized as one of the main factors of complex cell damage and aging of the body as a whole. These are very toxic compounds that can destroy the structure and disrupt the functioning of proteins and cell membranes. In addition, reactive oxygen species can damage nitrogenous bases in the composition of deoxyribonucleic acid (DNA) and cause various mutations. Oxidative stress is inextricably linked to many serious diseases of various systems and organs. Therefore, it is important not to miss the opportunity to contribute to the protection of your body from harmful influences.
For example, the structure of carnosine allows this molecule to directly take part in the processes of neutralization of the superoxide anion, hydroxyl radical, and a number of other reactive oxygen species [11]. This effect can be traced in the results of numerous studies [17].
Thus, it was shown in [18] that the use of carnosine in rats was associated with a decrease in the levels of oxidative stress markers and an increase in the activity of the superoxide dismutase enzyme, one of the key players in the antioxidant system of the cell. Chinese scientists obtained similar results in pigs, carnosine was used for 8 weeks [19].
In addition, the ability of carnosine to stimulate the processes of utilization of incorrect proteins has been described. The accumulation of such molecules is also associated with various age-related diseases. Another important protective function of carnosine is the ability to bind heavy metals such as copper, cobalt, nickel, cadmium, and zinc [11].
Beta-alanine and other sports supplements
To achieve even better results and get the most out of beta-alanine, it is possible to include additional products in the pharmaceutical support program that complement each other favorably.
For example, the work [20] demonstrated the positive effect of using a combination of beta-alanine and sodium bicarbonate (soda) in rowers; in particular, athletes were able to cover a distance of 2000 m faster. A similar increase in performance was recorded in swimmers [21] and in football players when performing a sprint test [22]. In the latter case, the dosage of beta-alanine was about 6 g per day, and sodium bicarbonate was about 22 g; the course of supplementation lasted 28 days. The use of beta-alanine with sodium bicarbonate is fundamentally important in cases where athletic performance is limited by metabolic acidosis, that is, excessive acidification [1].
Beta-alanine pairs well with other popular supplements as well. Thus, American scientists showed an increase in the percentage of muscle mass, a decrease in the percentage of fat and an improvement in strength indicators in people after 10 weeks of consumption of beta-alanine (3.2 g per day) and creatine (10.5 g per day) [23].
In addition, it is possible to use various multicomponent pre- and post-workout complexes, which, along with beta-alanine, include caffeine, branched chain amino acids (BCAA), whey protein, vitamins and much more. Researchers from the USA created a similar complex and demonstrated a significant increase in strength indicators, as well as an increase in the efficiency of the cardiovascular system [24].
Conclusion
In summary, beta-alanine is a critical supplement for combating muscle fatigue, increasing endurance and performance, and improving overall health. All this allows the athlete to work faster and more efficiently, and therefore achieve winning results.
Bibliography:
1. Trexler E, Smith-Ryan A, Stout J et al. International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition. 2015;12(1).
2. Hoffman J, Varanoske A, Stout J. Effects of β-Alanine Supplementation on Carnosine Elevation and Physiological Performance. Advances in Food and Nutrition Research. 2018;84:183-206.
3. Perrett M, Gothard M, Ludwig A. et al. Identifying a Source of Beta-Alanine and its Broader Implications in Arabidopsis thaliana by GC/MS. The FASEB Journal. 2017;31(1):626.1.
4. Van Thienen R, Van Proeyen K, Puype J. β-Alanine Improves Sprint Performance in Endurance Cycling. Medicine & Science in Sports & Exercise. 2009;41(4):898-903.
5. Sale C, Hill C, Ponte J et al. β-alanine supplementation improves isometric endurance of the knee extensor muscles. Journal of the International Society of Sports Nutrition. 2012;9(1):26.
6. Hoffman J, Landau G, Stout J et al. β-Alanine Supplementation Improves Tactical Performance but not Cognitive Function in Combat Soldiers. Medicine & Science in Sports & Exercise. 2014;46:31.
7. Favero S, Roschel H, Solis M. Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity. Amino Acids. 2012;43(1):49-56.
8. Sale C, Saunders B, Harris R. Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance. Amino Acids. 2009;39(2):321-333.
9. Saunders B, Elliott-Sale K, Artioli G et al. β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. British Journal of Sports Medicine. 2016;51(8):658-669.
10. Wilmore J, Costill D, Kenney L. Physiology of Sport and Exercise. 6th ed. Human Kinetics Publishers; 2015.
11. Boldyrev A, Aldini G, Derave W. Physiology and Pathophysiology of Carnosine. physiological reviews. 2013;93(4):1803-1845.
12. Stellingwerff T, Decombaz J, Harris R. et al. Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis. Amino Acids. 2012;43(1):57-65.
13. Shinohara T, Harada M, Ogi K. et al. Identification of a G Protein-coupled Receptor Specifically Responsive to β-Alanine. Journal of Biological Chemistry. 2004;279(22):23559-23564.
14. MacPhee S, Weaver I, Weaver D. An Evaluation of Interindividual Responses to the Orally Administered Neurotransmitter β-Alanine. Journal of Amino Acids. 2013;2013:1-5.
15. Smith-Ryan A, Woessner M, Melvin M et al. The effects of beta-alanine supplementation on physical working capacity at heart rate threshold. Clinical Physiology and Functional Imaging. 2013;34(5):397-404.
16. McCormack W, Stout J, Emerson N et al. Oral nutritional supplement fortified with beta-alanine improves physical working capacity in older adults: A randomized, placebo-controlled study. Experimental Gerontology. 2013;48(9):933-939.
17. Hipkiss A. Carnosine and its possible roles in nutrition and health. Advances in Food and Nutrition Research. 2009;57:87-154.
18. Aydin AF , Kucukgergin C , Ozdemirler-Erata G et al. The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged rats. Biogerontology 11:103-109, 2010.
19. Ma X, Jiang Z, Lin Y. et al. Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs. Journal of Animal Physiology and Animal Nutrition. 2010;94(6):e286-e295.
20. Hobson R, Harris R, Martin D. et al. Effect of Beta-Alanine with and without Sodium Bicarbonate on 2,000-m Rowing Performance. International Journal of Sport Nutrition and Exercise Metabolism. 2013;23(5):480-487.
21. De Salles Painelli V, Roschel H, de Jesus F. The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance. Applied Physiology, Nutrition, and Metabolism. 2013;38(5):525-532.
22. Ducker K, Dawson B, Wallman K. Effect of Beta Alanine and Sodium Bicarbonate Supplementation on Repeated-Sprint Performance. Journal of Strength and Conditioning Research. 2013;27(12):3450-3460.
23. Hoffman J, Ratamess N, Kang J. et al. Effect of Creatine and ß-Alanine Supplementation on Performance and Endocrine Responses in Strength/Power Athletes. International Journal of Sport Nutrition and Exercise Metabolism. 2006;16(4):430-446.
24 Kendall K, Moon J, Fairmann C et al. Ingesting a preworkout supplement containing caffeine, creatine, β-alanine, amino acids, and B vitamins for 28 days is both safe and efficacious in recreationally active men. nutrition research. 2014;34(5):442-449.
The composition of one serving (half a scoop)
- Beta-Alanine - 3000 mg
Directions for use Beta-Alanine Stark Pharm
Drink one to two servings in the morning and before training. On recovery days, it is enough only in the morning. The course of admission should not last more than 5 weeks. Then take a short break for 10-20 days. The supplement is compatible with any sports nutrition, especially with arginine and creatine.
Buy Beta-Alanine from Stark Pharm at the most affordable price we offer on our sports nutrition website. Our managers will help you choose the supplement individually for you. Order a free call or write to the online chat.
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